IRVINE, Calif., November 21, 2023 –TAE Life Sciences, a pioneer in advancing Boron Neutron Capture Therapy (BNCT) for cancer treatment, today announced groundbreaking findings from its recent research, heralding a new chapter in company’s pursuit of making Boron Neutron Capture Therapy (BNCT) a viable and globally accepted cancer treatment. The study focused on the development and boron delivery capabilities of Boronotyrosine (BTS), a novel borylated amino acid analogue that will redefine the cancer-fighting potential of BNCT.
Published in the Journal of Medicinal Chemistry, this study highlights BTS’s potential to improve BNCT, a cutting-edge cancer therapy modality that combines boronated drugs and a particle accelerator-based neutron source to precisely target and kill cancer cells with minimal damage to healthy tissue. This study demonstrates BTS’s unparalleled efficiency in delivering boron—a critical element in BNCT—to LAT1-expressing cancer cells, outperforming the only approved drug for BNCT, Boronophenylalanine (BPA), in both in vivo and in vitro models.
The findings reveal that BTS exhibits superior characteristics in terms of cellular uptake, demonstrating a 2-fold to 4-fold greater uptake in vitro compared to BPA. Furthermore, boron retention is significantly higher within cancer cells which retain nearly 60% of the ingested boron after 18 hours, whereas less than 20% is retained after 18 hours with BPA. Notably these results also translated to higher boron delivery over longer periods of time in in vivo experiments. Lastly, the tumor-to-blood ratio with BTS was found to be markedly improved, as high as 28 to 1 compared to only 6 to 1 for BPA, showcasing significantly improved performance in targeting tumors while minimizing exposure to healthy tissue. All these key attributes may be instrumental in enhancing the efficacy of BNCT while minimizing damage to healthy tissues.
“TAE Life Sciences’ commitment to scientific rigor and innovation is evident in this study,” said Dr. Kendall Morrison, Chief Scientific Officer at the company. “The publication of our findings in the Journal of Medicinal Chemistry underscores the meticulous research and robust scientific foundation behind BTS’s development and testing.”
This breakthrough study cements TAE Life Sciences’ position as a frontrunner in pioneering cancer treatment advancements in the field of radiation oncology. The promising results pave the way for further research and clinical applications, reaffirming the company’s dedication to transforming cancer care.
For more information about TAE Life Sciences, Alphabeam, and the company’s proprietary boronated BNCT drugs, please visit www.taelifesciences.com.
About TAE Life Sciences
TAE Life Sciences is a privately held biotechnology company committed to developing a new biologically targeted radiation therapy based on Boron Neutron Capture Therapy (BNCT). TAE Life Sciences is the only company developing the next-generation targeted boron drugs and low-energy accelerator-based neutron system optimized for an in-hospital BNCT program that delivers cancer-killing radiation with cellular-level precision to treat patients with aggressive and refractory cancers. TAE Life Sciences’ Alphabeam neutron system and targeted boron drugs are currently in development and have not been approved for sale. More information about TAE Life Sciences is available at www.taelifesciences.com.
Irvine, Calif., November 8, 2023 –TAE Life Sciences, a pioneer in advancing Boron Neutron Capture Therapy (BNCT) for cancer treatment, proudly announces it has earned the 2023 Biotech Breakthrough Award for Oncology Innovation of the Year. This prestigious accolade acknowledges TAE Life Sciences’ pioneering work in radiation oncology and highlights the role its innovative Alphabeam™ Neutron System and proprietary boronated drugs are playing in making Boron Neutron Capture Therapy (BNCT) a mainstay of modern oncology.
“The advancements we’ve made hold the potential to be applied across a broader range of clinical scenarios, expanding the horizons of BNCT as a next-generation cancer treatment,” said TAE Life Sciences’ CEO, Rob Hill. “Thank you to BioTech Breakthrough for validating our work. With our BNCT approach, empowered by Alphabeam and boronated drugs, we are leading the way to faster, more effective, and safer treatment options for a range of difficult-to-treat cancers that is sure to enhance patient outcomes and save lives.”
The Biotech Breakthrough Award symbolizes our commitment to shaping the future of cancer treatment. TAE Life Sciences’ Alphabeam Neutron System generates high-intensity, precision-focused, low-energy neutrons, revolutionizing BNCT. This innovative approach provides highly targeted cancer treatment with minimal collateral damage, reducing the impact on healthy tissue.
At the core of this achievement is Alphabeam’s capacity to deliver thermal neutrons, enabling the interaction between boron-10 and tumor cells. This interaction results in the release of high-energy alpha particles and lithium nuclei, destroying tumor cell DNA and ultimately killing the cancer cells while sparing surrounding healthy tissue. This groundbreaking technology not only holds promise for head and neck cancers but also eliminates the need for dangerous nuclear reactors, making it a safer, cost-effective, and versatile alternative for cancer treatment.
“TAE Life Sciences is spearheading pivotal advancement in biotech. By combining the precision of Alphabeam with the selectivity of their boronated drugs, the company is setting the stage for a paradigm shift in cancer therapy,” said Bryan Vaughn, Managing Director of BioTech Breakthrough Awards. “Historically, BNCT required a nuclear reactor as a neutron source, which is extremely expensive and impractical for hospitals to adopt and maintain. TAE’s Alphabeam system eliminates this need and offers flexibility for various clinical settings. This versatility, coupled with its potential to treat various types of cancers, grants TAE our ‘Oncology Innovation of the Year’ award.”
Complementing Alphabeam is TAE Life Sciences’ proprietary boronated drug, TC220, which offers numerous advantages over conventional boronophenylalanine (BPA). Pre-clinical studies have shown TC220’s superior ability to deliver boron effectively to tumor cells, expanding the horizons of BNCT as a next-generation cancer treatment.
The Alphabeam system’s versatility enhances its market potential, as it can be integrated into existing medical infrastructures and offers the promise of reducing cancer treatment costs. This groundbreaking technology is being deployed to cancer hospitals worldwide, signaling a transformative shift in oncology.
TAE Life Sciences is committed to advancing the frontiers of oncology through innovation and patient-focused care. This award is a testament to the company’s dedication to making a profound and positive impact in biotechnology.
For more information about TAE Life Sciences, Alphabeam, and the company’s proprietary boronated BNCT drugs, please visit www.taelifesciences.com.
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About TAE Life Sciences
TAE Life Sciences is a privately held biotechnology company committed to developing a new biologically targeted radiation therapy based on Boron Neutron Capture Therapy (BNCT). TAE Life Sciences is the only company developing the next-generation targeted boron drugs and low-energy accelerator-based neutron system optimized for an in-hospital BNCT program that delivers cancer-killing radiation with cellular-level precision to treat patients with aggressive and refractory cancers. TAE Life Sciences’ Alphabeam neutron system and targeted boron drugs are currently in development and have not been approved for sale. More information about TAE Life Sciences is available at www.taelifesciences.com.
BREA, CALIF., November 2, 2023 — Monoprice, the leader in value-packed consumer electronics and accessories, today announced its PowerCache line of portable power solutions. Designed to offer a cleaner, quieter alternative to traditional gas generators, PowerCache portable power stations are a versatile and reliable source of power for a wide range of applications, whether you’re at work, home, or play.
PowerCache power stations showcase the uncompromising commitment to excellence, performance, and value that Monoprice has been known for since day one. With an industry-leading cost-per-watt-hour, the PowerCache line is set to make larger-capacity portable power stations boasting the latest options and features more affordable.
Inputs: 12-28V DC Charge Port, 18V 100W Max Solar Input
Outputs: 1x 120V AC 300W Max, 1x USB-A QuickCharge 3.0 18W Max, 1x USB-A 5V 2.4A 12 Max, 1x USB-C PD 60W Max, 1x 12V 10A DC Car Port, 2x 12V 10A DC 5525 120W Max Shared
Features: Pure Sine Wave AC output for sensitive electronics and appliances with motors, integrated info-rich LCD display, 3W LED Light (Fixed, Strobe, SOS modes)
Inputs: 29.4-50V DC Charge Port, 36V DC 100-400W Solar Input
Outputs: 2x 120V AC 600W Max, 1x USB-A QuickCharge 3.0 18W Max, 1x USB-A 5V 2.4A 12W Max, 1x USB-C PD 60W Max, 1x 12V 10A DC Car Port 120W Max, 2x 12V 10A DC 5525 120W Max Shared
Features: Pure Sine Wave AC output for sensitive electronics and appliances with motors, integrated info-rich LCD display, 3W LED Light (Fixed, Strobe, SOS modes)
Battery Chemistry: Lithium Iron Phosphate (LiFePO4)
Total Capacity: 1,075Wh
Total Power Output: 1,000W Continuous / 2,000W Peak
Inputs: 29.4-50V DC Charge Port, 36V DC 100-400W Solar Input
Outputs: 2x 120V AC 1,000W Max, 1x USB-A QuickCharge 3.0 18W Max, 1x USB-A 5V 2.4A 12W Max, 1x USB-C PD 60W Max, 1x 24V 10A DC RV/Car Port 240W Max, 1x 12V 10A DC Car Port 120W Max, 2x 12V 10A DC 5525 120W Max Shared
Features: Pure Sine Wave AC output for sensitive electronics and appliances with motors, integrated info-rich LCD display, 3W LED Light (Fixed, Strobe, SOS modes)
Warranty: 2 Years
A Cleaner, Quieter Alternative to Traditional Gas Generators
Scott Sablan, Business Unit Manager, Monoprice, commented, “In today’s fast-paced world, reliable and portable power solutions are essential for modern lifestyles. With the PowerCache line of portable power stations, we’re not just offering power; we’re offering peace of mind. These products are designed to keep you connected and powered up wherever life takes you, without the noise and pollution of traditional generators.”
PowerCache Power Stations capture and store energy from various sources, including any standard 120V AC wall outlet, solar panels (sold separately), or a car’s standard 12V accessory outlet. These units operate almost silently, delivering clean, safe, hassle-free power when you need it most.
The compact form factor of PowerCache Power Stations makes them ideal for both planned and unplanned adventures. Keep mobile devices and essential electronics powered longer during road trips, camping, tailgating, garage work, backyard activities, and emergency situations like blackouts and roadside emergencies.
Independent AC and DC supply circuits power a versatile array of port options, including pure sine wave 120-volt AC, USB-C PD, USB-A, 12V Car Port, and multiple DC outputs – all of which can be operated simultaneously, on demand, outputting up to 300, 600, or 1000 Watts, depending on the model. Built-in LED lighting provides added functionality in the form of task and emergency lighting.
PowerCache Power Stations are UL-certified to meet the industry’s strictest safety standards and feature multiple built-in safety features, including overload and short-circuit protection. With proper use, the PowerCache 300 Lithium, 600 Lithium, and 1000 Lithium are designed to provide years of safe, reliable operation.
In addition to the PowerCache Power Stations, Monoprice also offers a range of complementary portable solar panels designed to work seamlessly with supported power stations from all brands, offering an eco-friendly and sustainable power solution for outdoor enthusiasts and emergency preparedness.
For more information and to stay updated on the latest developments, please visit www.monoprice.com.
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About Monoprice, Inc. (DBA Monoprice.com)
Located in Brea, Calif., Monoprice, Inc. is an e-commerce leader specializing in high-quality yet affordable electronics and tech products. As an industry innovator, Monoprice fills a void in the consumer technology market by delivering exceptional products that are on par with the best-known national brands at prices far below the retail average with incomparable speed and service. Maintaining a business philosophy that focuses on the needs of its customers, the company strives to bring simplicity, fairness and confidence to consumers and businesses shopping for big-ticket electronics and tech accessories. For more information about Monoprice, follow us on Facebook, Twitter, LinkedIn, YouTube and the Monoprice Blog.
